How much will it cost to synthesize AMP and GMP?
The biosynthesis of both AMP and GMP requires the hydrolysis of several high-energy bonds. To produce IMP from D-ribose 5-phosphate requires the hydrolysis of five high-energy bonds (one PPi and five ATP). To convert IMP to AMP requires the hydrolysis of one more high-energy bond (from GTP). And to convert IMP to GMP requires the hydrolysis of two high-energy bonds — one ATP and one PPi.
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