You know about Protein folding? - Cuntorio

Folding occurs step-wise with several intermediates unfolded/secondary structure/domains/molten globule/native tertiary structure. The steps include, a collapsed structure (molten globule) occurs very quickly. steps between molten globule and native tertiary structure usually occur slowly (a) intermediates are isolatable (b) multiple pathways are possible. Folding is driven by hydrophobic forces.